In New York City, high-strung equity trader Joy Ellis McNally is dumped by her fiancé at a surprise birthday party she throws for him. At the same time, easy-going carpenter Jack Fuller is fired from his job by his father, Jack, Sr. Both become emotionally distraught and, with best friends Toni "Tipper", a bartender, and Jeff "Hater", a lawyer, take a debauched trip to Las Vegas.