When the actions of Jason Bourne spark a fire that threatens to burn down decades of research across a number of secret intelligence agencies, Eric Byer, the man who built the programs, decides he must sacrifice one of them: Outcome. Aaron Cross, one of Outcome's six agents, and research scientist Marta Shearing go on the run when Byer targets them for termination. But Cross proves to be a far deadlier target than Byer realizes.