Famed novelist Paul Sheldon is the author of a successful series of Victorian era romance novels featuring a character named Misery Chastain. Wanting to focus on more serious stories, he writes a manuscript for a new novel that he hopes will launch his post-Misery career. While traveling from Silver Creek, Colorado to his home in New York City, Paul is caught in a blizzard and his car goes off the road, rendering him unconscious. A nurse named Annie Wilkes finds Paul and brings him to her remote home.