Following the grisly suicide of the U.S. Ambassador to Great Britain, 32-year-old international conglomerate CEO Damien Thorn is appointed in his place, an office his adoptive father, Robert Thorn, once held. Having fully embraced his unholy lineage and having run his company for seven years, Damien now attempts to reshape his destiny by halting the Second Coming of Christ. However, Father DeCarlo, a priest from the Subiaco monastery where Father Spiletto spent his final days and who has observed Damien from afar since his adopted father's death, acquires the Seven Daggers of Megiddo that were dug out of the ruins of the Thorn Museum in Chicago. Joined by six other priests, DeCarlo plans to kill Damien while finding the Christ child. Meanwhile, Damien becomes romantically involved with journalist Kate Reynolds. Learning of his assassins and killing all but DeCarlo over time, he proceeds to mold Reynolds's young son Peter into a disciple by playing on the boy's desire for a father figure.