When new student Cady Heron makes the major misstep of falling for Aaron Samuels, she finds herself prey in Regina George's crosshairs, leader of the elite group of popular girls called "The Plastics." As Cady sets to take down the the group's apex predator with the help of her outcast friends Janis and Damian, she must learn how to stay true to herself while navigating the most cutthroat jungle of all: high school.