Nicky Marotta (Robin Johnson) and Pamela Pearl (Trini Alvarado) are two teenage girls who meet in the New York Neurological Hospital, where they're both being examined for mental illness. Pamela is depressed and insecure, and she's neglected and exploited by her father, David Pearl (Peter Coffield), a prominent and wealthy commissioner running a campaign to "clean up" Times Square. Nicky is a tough-talking street kid with musical aspirations, sent to the hospital for an evaluation after an altercation with police. Sharing a room, the brash Nicky and shy Pamela become friends. Nicky admires Pamela's poetic spirit; Pamela admires Nicky's forthright attitude and resents the condescending way in which the doctors treat her. Nicky is released from the hospital and later returns, ostensibly for an appointment with her social worker, Rosie Washington (Anna Maria Horsford), but really to break Pamela out. Both girls escape the hospital, steal an ambulance, and hide out in abandoned warehouse on the Chelsea Piers, making a pact to scream out each other's names in times of trouble.