Salman Khan is a Bollywood actor, who is on a live tour near Delhi, where his private jet crashes. Luckily, he survives and in a lounge, he meets a girl (Katrina Kaif). She tells him a story, about six friends and their boss who all work together at a Mumbai-based call centre. They are instructed never to reveal their location and speak with an American accent by a Boston-based company. There is Shyam (Sam) (Sharman Joshi), Priyanka (Gul Panag), Varun (Sohail Khan), Esha (Isha Koppikar), Radhika (Amrita Arora) and Military Uncle (Sharat Saxena). Their boss, Subhash Bakshi (Dalip Tahil), attempts to further his career by plagiarising software, agreeing to lay off 40% of the Indian workforce, and re-locate to Boston. Although these six friends work together, they still go through some struggles ;Shyam tries his best to reconcile with Priyanka after their breakup, Esha gets annoyed by Varun when she thinks he likes her, Radhika is heartbroken when her husband Anuj (Arbaaz Khan) cheats on her with his girlfriend, and Military Uncle wants a visa to see his son and grandson. Bakshi turns their names into American names such as turning Shyam into Agent Sam, Varun to Agent Victor, Esha to Elizabeth, Priyanka to Pearl, and Radhika to Rebecca.