Japan has entered a new era. Hiden Intelligence, the country's most thriving technology company that specializes in artificial intelligence (AI), has developed a way to utilize these A.I.s in a humanoid form, known as the Humagear. These virtually identical humanoid androids have become a staple in everyday life, to the general public as well as the private sectors. After his grandfather's death, a young but failing stage comedian named Aruto Hiden bears witness to several terrorist attacks orchestrated by MetsubouJinrai.net, prompting the creation of an anti-Humagear military squad, A.I.M.S.. Upon inheriting his late grandfather's company and the Zero-One Driver, Aruto becomes Kamen Rider Zero-One and finds himself caught in the crossfire between MetsubouJinrai.net and ZAIA Japan, led by Gai Amatsu who wishes to rid the Humagear from society and take over the world.