The show follows Mack, a lovable, moose-like lummox, and Moxy, a feisty, raccoon/fox-inspired go-getter as they take off on another adventure. Together with a helpful Trooper (child), they set out to rescue another Great Helpee in a far off mystical place called HelpeeLand. Along the way, Mack & Moxy meet a new Friend-In-Need who introduces Mack & Moxy (and the kids at home) to a new important cause.