The police investigate a string of murders committed by the Creeper (Rondo Hatton), a mysterious killer with a hideously disfigured face. The Creeper attacks and murders Professor Cushman (John Hamilton (actor)), a professor from the nearby Hampton University. Later that night, the killer approaches a woman named Joan Bemis (Janelle Johnson) in front of her home and identifies himself as Hal Moffet. Joan screams hysterically at the sight of him until he is driven to kill her. When police cars approach, the Creeper climbs the fire escape of a city tenement building to escape and enters the apartment of Helen Paige (Poni Adams), a blind pianist. Unable to see the Creeper's deformed face, Helen is not afraid of the intruder, even when he admits to fleeing. When police officers knock on her door, failing to identify themselves, Helen encourages him to hide in her bedroom, where he escapes through the window.