A prologue introduces us to Dr. Austin Sloper (Albert Finney), a New York City doctor and resident of a large house on Washington Square Park whose wife dies in childbirth, leaving a daughter, Catherine (Jennifer Jason Leigh), to be raised by her father. As a child, Catherine is overweight, clumsy, and untalented; however, she is also a sweet, affectionate child. She adores her father and tries hard to please him, but he considers her a disappointment and treats her with ironic condescension. His thoughts are still much occupied with his beloved wife and with a promising son who died before Catherine was born, and he privately – but bitterly – resents his only surviving child for causing his wife's death.