Barry Egan is a single man who owns a company that markets themed toilet plungers and other novelty items. He has seven overbearing sisters who ridicule and emotionally abuse him regularly and leads a lonely life punctuated by fits of rage and anguish. In the span of one morning, he witnesses an inexplicable car accident, picks up an abandoned pump organ from the street, and encounters Lena Leonard, a coworker of one of his sisters, Elizabeth. Lena had orchestrated this meeting after seeing him in a family picture belonging to Elizabeth.