In Black Lake, Maine, mercenary Beach and Jim Bickerman (who survived from an attack by a crocodile in ''Lake Placid: The Final Chapter'', now lost his eye, hand and leg, replaced with a eye patch, hook and wooden leg) capture a female giant crocodile. They take it back to their truck, where two scientists crossbreed with a female giant anaconda to perfect the Blood Orchid serum. However, the crocodile escapes and kills a scientist, and frees the female and two male anacondas before causing the truck to explode and destroying part of the electric fence, keeping the crocodiles in Black Lake, though Beach, Bickerman, and the remaining scientist survive. However, a small group of crocodiles also escape.