Jesse (Robert Wagner) and Frank James (Jeffrey Hunter) ride with their gang into Northfield, Minnesota for a raid. While robbing a bank, gun fighting breaks out and two of the gang are killed. The James brothers and another gang member head out of town and hide out while investigators from the Remington Detective Agency search for James to receive a $30,000 reward. While the three are hiding, the film tells the story of how the James brothers came to be criminals in flashback.