David (Campbell Scott) and Dana Hurst (Hope Davis) are dentists who are married with three daughters and share a dental practice in Westchester County, New York. Dana is in the chorus of a community opera production, and when David goes backstage to give her a good luck charm, he sees her in the arms of another man. As he contemplates how to handle this, he begins having imaginary conversations with a difficult former patient (Denis Leary). When the whole family gets the flu, everything is brought to a head.