After crudely trying to sew his monstrous former conjoined twin Belial back on to his side at the end of the previous film, Duane Bradley is re-separated from Belial and put in a straitjacket and padded cell in Granny Ruth's haven for "unique (deformed) individuals". After several months of captivity Duane is released by Granny Ruth, who is preparing to take everyone on a road trip to the home of her ex-husband Doctor Hal Rockwell, who will help in giving birth to Belial's equally misshapen girlfriend Eve's babies; before leaving for the trip, Granny Ruth sternly tells Duane to stay away from Belial, who has stopped speaking to Duane telepathically after Duane's attempt to put them back together.