In Murphysboro, Illinois, Tammy Banks (Melissa McCarthy) strikes a deer on the way to her job at the fast food restaurant Topper Jack's, damaging her vehicle; when she arrives, her supervisor, Keith Morgan (Ben Falcone), is forced to dismissal (employment) her from the restaurant. After her car breaks down on the way home on Illinois Route 13, she walks home to find her husband, Greg (Nat Faxon), eating a romantic meal with their neighbor, Missi (Toni Collette). Tammy leaves in frustration and walks two doors down to her parents' house.