Kattula Katamarayudu (Pawan Kalyan) is a brave person living in a village called Oddaanchatram, who lives with his four brothers. The elder brother loves the younger ones to the core, and sacrifices his happiness for their good. They are often caught in fights and they are proud of it. Advocate Bail Lingam (Ali) bails them out whenever legal issues arise because of their brawls. Katamarayudu hates the idea of marriage as he feels that his wife might create disharmony among brothers. Though the four younger brothers say that they don't want to either fall in love or get married, when Kattula Katamarayudu is not around, they all have their secret lovers. Now, in order to get the green light for their love stories, they learn through his brother's childhood friend Collector that Kattula Katamarayudu, in school, was in love with a girl named Avantika and his brothers hatch a plan to find her and reintroduce her to Kattula Katamarayudu, so he can fall for her all over again. But she's married now and has kids. So the brothers conspire to do the most logical thing, which is to find another woman named Avantika (Shruti Hassan) because, you see, Kattula Katamarayudu was not in love with that girl so much as her name, and when he meets another (completely random) girl with that name, he is sure to lose his heart to her, just because she bears that name. Though initially reluctant later Kattula Katamarayudu himself falls in love with her. He clashes with a businessman called Radia (Pradeep Rawat (actor)) to take care of market in the village. Radia tries to kill Kattula Katamarayudu's brothers while Kattula Katamarayudu kidnaps Radia's son Juttu Ranga (Ayyapa Sharma) after clashing, Kattula Katamarayudu orders Radia to leave this village.