Ashok (Saif Ali Khan) and Kumar (Riteish Deshmukh) are best friends, whereas Shanaya (Tamannaah Bhatia) and Mishti (Bipasha Basu) are their love interests. Ashok's father is a multi millionaire but has been in a coma for the last six years, while his wicked Mamaji (Ram Kapoor) teams up with an evil doctor, Dr. Khan (Nawab Shah (actor)) to get rid of Ashok and take over all his property. During a board meeting Singh (Ram Kapoor) mixes a medicine in Ashok and Kumar's drink and they both start behaving like dogs.