Stand-up comedy had always been a male domain. Only a tiny handful of women have broken out of the brutal world of comedy clubs to become household names. After decades of fighting for a place in the spotlight, things have finally shifted. This documentary journeys backstage and on the road with veteran comedians, rising stars and novices to discover how an intrepid group of boundary-breaking females are changing the game and exploring what it takes to become the voices of their generation and their gender.