The film centers on New Yorkers who are lonely and emotionally lost in the big city. Rose (Graham), an ophthalmology, has separated from her husband (Baldwin), a school teacher, and is in deep mourning over the recent death of their two-year-old son, who accidentally fell out a window. Tomaso (Chianese) is a painter who has just learned that he's going blindness. Simon (Rasuk) is a 20-year-old photo shop clerk living at home with his alcoholism mother.