Dr. Julian Blair is engaged in unconventional research on human brain waves when his wife Helen (Shirley Warde) is tragically killed in an auto accident. The grief-stricken scientist becomes obsessed with redirecting his work into making contact with the dead and is not deterred by dire warnings from his daughter Anne (Amanda Duff), his research assistant Richard (Richard Fiske), or his colleagues that he is delving into forbidden areas of knowledge. He moves his laboratory to an isolated New England mansion where he continues to try to reach out to his dead wife. He is aided by his mentally-challenged servant Karl (Ralph Penney) and abetted by the obsessive Mrs. Walters (Anne Revere), a phony medium, who seems to exert a sinister influence over him. When their overly curious housekeeper discovers the truth about their experiments, her death brings the local sheriff in to investigate.