Married doctors Niles (John Eldredge (actor)) and Carole Nelson (Kay Francis) save the life of a shot gangster. Joe Gurney (Humphrey Bogart), the patient's boss, gives Niles $500 as a reward, and suggests he take his "million dollar hands" uptown, where he can treat the rich. Niles takes his suggestion, but soon neglects his practice for his addiction: betting on the horses.