Dr. Anton Phibes, a famous concert organist and expert in theology and music, is thought to have been killed in a car crash in Switzerland in 1921, while racing home upon hearing of the death of his beloved wife, Victoria, during surgery. Phibes survived the crash, but he was horribly scarred and left unable to speak. He remakes his face with prosthetics and uses his knowledge of acoustics to regain his voice. Resurfacing secretly in London in 1925, Phibes believes his wife was a victim of incompetence on the part of the doctors, and he begins elaborate plans to kill those he believes are guilty.