Blood Brother takes place on the mean streets of a city in decay, where a recently released convict begins to take murderous revenge against his childhood friends, whom he believes let him take the fall for a crime they collectively committed. As the bodies start piling up, one of the friends Sonny (Trey Songz), now a cop, will stop at nothing to put an end to the murderous rampage and to right the many wrongs of their tragically violent past. It also includes China Anne McClain, Jack Kesy, Hassan Johnson, Fetty Wap, and Jessica Re' Williams as Donna.