Dr. Jeff Weitzman (Dennis Boutsikaris) is a psychologist working in a sanitarium in New Jersey. His primary patients are Billy, Henry, Jack and Albert. Billy (Keaton) is the most normal of the group and their unofficial leader, though he is a pathological liar with delusions of grandeur and violent tendencies. Henry (Lloyd) is obsessive/compulsive and he has deluded himself into thinking he is one of the doctors at the hospital, often walking around with a clipboard, lab coat and stethoscope. Jack (Boyle) is a former advertising executive who believes he is Jesus Christ. Finally, Albert (Furst) is a man-child who only says things he hears during baseball games, particularly from former ball player and commentator Phil Rizzuto.