Sherlock Holmes (Basil Rathbone) pretends to be a Nazi spy to aid scientist Dr. Franz Tobel (William Post Jr.) and his new invention, a bombsight, in escaping a Gestapo trap in Switzerland. Holmes and Franz fly to London, where Holmes places him under the protection of his friend, Doctor Watson (Nigel Bruce). The scientist slips away against Holmes' instructions for a secret reunion with his fiancee, Charlotte Eberli (Kaaren Verne), and gives her an envelope containing a coded message. He tells Charlotte to give it to Holmes if anything should happen to him. Leaving Charlotte's apartment, an attempt to abduct him by German spies is foiled by a passing London Constable.