The movie opens with an interview with a body crab named Buster living on a bikini-clad woman. The body crab sees Man (Tommy Chong) passing by and jumps on his beard. Man quickly pulls him out and throws him away. Pedro De Pacas (Cheech Marin) is shown driving just up the street from the hitchhiking Man. Pedro sees him and stops the car to give Man a ride. Man gets in and they both peel off, sending the body crab flying. The body crab smells the strong marijuana scent left behind from their car and gives chase. Pedro and Man smoke a joint together and drive through traffic as Pedro admires the street lights. A police car suddenly appears from behind and tails them. Man quickly decides to eat all the drugs in the car to avoid being caught with them. After Man does that the police car passes them without pulling them over. The body crab then gets hit by a train while it is still looking for them.