Schlitzie: One of Us is a love letter to the 4-foot-tall performer, who was born with microcephaly, and made his most notable cultural impact via the 1932 classic film Freaks. The Ramones immortalized him with a song; the FX series "American Horror Story: Freakshow" featured a character based on him, as well as in the comic strip "Zippy the Pinhead." The documentary examines how he touched the hearts of many and made an impact on pop culture, while imparting a hopeful message of acceptance and tolerance. In addition to Schlitzie, the film features those born different, who have made an impact and thrived despite their obstacles. Artists on the Autism Spectrum have created the film's animation and musical score.