''Read It and Weep'' begins with freshman Jameson "Jamie" Bartlett (Kay Panabaker), who has three best friends named Connor (who has a crush on her) (Jason Dolley), Lindsay (Marquise Brown), and Harmony (Alexandra Krosney), a brother named Lenny Bartlett (Nick Whitaker) and a very mean enemy named Sawyer Sullivan (Allison Scagliotti) (who she calls "Myrna" in her journal and the novel), whose boyfriend Marco is the object of Jamie's affection. She also owns a Tablet computer which she writes in every day. In that journal she writes about a character named "Isabella," or "Is" (Danielle Panabaker), a popular girl with incredible powers based loosely on herself. Jamie uses her tablet PC as her own little universe, where she tells about different people, and stories, but in actuality is her own life, just a little more imaginative.