The movie opens as Josh Nichols (Josh Peck) runs into the kitchen and tries to tell his step-sister Megan Parker (Miranda Cosgrove) how he got into a prestigious creative writing class. She, however, makes a smoothie, which drowns out his conversation. He and his step-brother, Drake Parker's (Drake Bell) parents Audrey and Walter (Nancy Sullivan (American actress), Jonathan Goldstein (actor)) are to take a ten-day cruise to Acapulco, during which Megan will stay at a friend’s house in Denver. Josh begins to write a story about his greatest adventure for his class but is unable to recall one, concluding that he has a boring life. Meanwhile, Drake's band manager let a great gig slip through his fingers, and Drake and his band then have to perform at the "B'Nai Shalom Home for The Elderly." Drake, enraged, fires his current manager and lets Josh take his place. Shortly before their parents’ departure, Drake selfishly leaves for over an hour and finally returns, causing Megan to nearly miss her flight to Denver. However, Drake accidentally puts Megan on the wrong flight, and she ends up en route to Los Angeles, California. They try to open the plane doors, but are caught and searched by the T.S.A. They attempt to call Megan's cell phone, but she has accidentally left it with Josh. Soon after, Drake and Josh decide to fly to L.A. to get her. Drake and Josh sit in separate seats, and as per usual, Drake gets better seating companions: women. Josh moves away from a disgusting family he sat next to and sits next to a criminal who has stolen a U.S. Treasury. While their plane goes through turbulence, the fat lady Josh sat next to falls over on him. His G.O. (MP3 player) is switched with the criminal's, who has stored blueprints for counterfeit money on it. Meanwhile, Megan calls for a limo in L.A. and arrives at the Chambrulay Hotel, a luxury hotel by the beach. Once Drake and Josh find that Megan is okay, the boys decide to stay in L.A. for a while. Josh decides to go on hi