''Dil Ne Jise Apna Kahaa'' begins with Rishabh (Salman Khan) and Pari (Preity Zinta) who are deeply in love. He is a wealthy young man, working in an advertising agency while she is a hardworking, dedicated doctor. They marry and soon Pari is pregnant. Pari has a dream to create a hospital for children. Tragically, she is involved in an accident and dies in hospital. Pari's last wish was to donate her heart to her patient Dhani (Bhumika Chawla). Rishabh is devastated and opposes the plan to donate the heart; he goes ahead with Pari's last request: the creation of a children's hospital.