León Robles is a Spanish psychiatrist who is in crisis with their own profession , newcomer to the Metropolitan Hospital of a large American city , looking for her twin sister Lola Robles , who suffers from a severe mental disorder and has been missing for more than two years. There he meets with Charo Rios , director of the psychiatric hospital wing and former lover of Leon. Unexpectedly , Leon gives a sample of his brilliant and non- traditional treat patients , solving the case of a patient , which is worth to be named, without imagining or seek new chief of psychiatry . From this moment , Leon face in each episode new and varied psychiatric cases , while garnering admiration and rejection by the staff of physicians . Meanwhile, he continues the relentless pursuit of his sister Lola , key to resolve their own personal conflicts piece.