Set in a coffee shop located inside a university campus, Heartful Cafe follows the story of Heart Fulgencio. For Heart, The Heartful Cafe is more than just a stomping ground for coffee drinkers; rather, it's a place where all the magic happens. Despite having experienced heartbreak herself, Heart enjoys playing cupid for her customers who seek help regarding matters of the heart. When her cafe turns into shambles, Ace Nobleza, a handsome co-investor comes into her life and rescues her.