The series chronicles the rocky coexistence of Larry Appleton and his distant cousin Balki Bartokomous. A Wisconsin native, Larry, who comes from a large family with numerous brothers and sisters, has just moved into a new apartment in Chicago, and is experiencing his first joys of newfound privacy when Balki, a hitherto unknown cousin from a Greek-like island in the Mediterranean called Mypos, drops by to live with him. Balki, a shepherd by trade, interprets what little he knows about the United States by relying on his own recollections of American pop culture, which are often out-of-context. After initially gently rebuffing his cousin's request to stay at his apartment, Larry, an aspiring photographer, decides to take Balki under his wing and teach him about American life...