The story follows Sid (Riteish Deshmukh) and Adi (Tusshar Kapoor), roommates and good friends. Adi is a struggling actor, whilst Sid is a struggling DJ who admires his own dog Sackru more than himself, Adi and Sid manage to meet ends by offering Sackru for mating in dog breeding centres where Sackru mates with female dogs of his breed on playing a specific music by Sid. Adi falls in love with Simran (Neha Sharma) who works at a call-center, Adi proposes Simran for marriage but she refuses and lies to him that she is lesbian, while Sid falls for Anu (Sarah Jane Dias) whom he meets at a fashion show. Then Anu and Simran go to Goa to meet Anu's father, Marlo (Anupam Kher) who has gone mad ever since the death of his mother. In Goa, Baba 3G (Chunky Pandey), a conman posing as a priest tells Marlo that his dead mother has been reincarnated into a female dog Rosemary. When Adi and Sid take Sackru and follow the girls to Goa and Sid meets Marlo where Sackru copulates with the female dog Rosemary.