Tadeo Jones (Tad Stones in the English version and voiced by Kerry Shale) is a bricklayer who lives in Chicago, working on the construction of the city's Chicago Transit Authority. Ever since he was five years old, he has dreamed of being a professional archaeologist. After being fired from his job as a bricklayer for daydreaming and for his dog urinating on the construction foreman, Tad visits his friend Professor Humbert (voiced by Mac McDonald), asking for the professor's help in investigating an apparently vintage bottle of Coca-Cola Tad found on the construction site. The professor receives a letter from his friend Professor Lavrof summoning him to Peru to re-unite his half of a stone "key" that will unlock the legendary Incan city of Paititi. Arriving at the airport, Professor Humbert suffers an accident after taking the wrong pills and is taken to the hospital. Meanwhile, a member of the nefarious firm Odysseus Inc. is spying on them and sends the photo to the other members who are in the Sechura Desert.