46-year-old former high school dropout and self-described "junkie whore" Jerri Blank is released from prison and returns to her childhood home. She discovers her mother has died, her father, Guy, has remarried to the hateful Sara Blank, and she has an arrogant half-brother Derrick. To make matters worse, her father is in a "stress-induced coma". Taking the suggestion of the family doctor literally, Jerri decides to pick her life back up where she left it, beginning her high school all over again as a freshman at Flatpoint High.