A meteorite crashes near Arbeville, Colorado. An elderly transient discovers, within the sphere, a massive slime mold-like substance that adheres to his hand. Three high school students, Brian, Meg and Paul, take him to a hospital. After Brian leaves, Paul witnesses the lower half of the transient melting from exposure to the Blob. As he calls for help, the Blob drops on top of him. Meg arrives to see Paul being devoured by the growing Blob. While she tries freeing him, his arm dissolves off, Meg is thrown against a wall and knocked unconscious, and the Blob fully dissolves Paul and oozes out of the hospital.