Deeply religious April Epner, a 39-year-old Brooklyn elementary school teacher, finds her life derailed by a series of events over which she has no control. Her husband Ben abruptly leaves her, her abrasive adoptive mother Trudy passes away the following day, and shortly after she is contacted by Alan, a representative of Bernice Graves, the flamboyant host of a local talk show, who introduces herself as her biological mother.