When Nicky (John Cassavetes) calls Mikey (Peter Falk) yet again to bail him out of trouble—this time a contract on his life for money he stole from his mob boss—Mikey, as always, shows up to help. Overcoming the obstacles of Nicky's paranoia and blind fear, Mikey gets him out of the hotel where he has holed up, and starts to help him plan his escape, but Nicky keeps changing the plan, and a hit man is hot on their trail. As they try to make their escape, the two friends have to confront issues of betrayal, regret, and the value of friendship versus self-preservation.