While in her house alone teenager Screw Frombehind (Aimee Graham) is attacked by "The Killer". While being chased, Screw accidentally runs into a Bug zapper and is electrocuted. The killer's disappointed he was not the cause of her death, lights a cigarette, leading to melting his Jason Voorhees mask, revealing a Ghostface (Scream) underneath. The next day new kid Dawson Deery (Harley Cross) registers at Bulimia Falls High School, meeting a new group of friends including Boner (Danny Strong), Slab (Simon Rex), Barbara (Julie Benz) and Martina (Majandra Delfino), to whom Dawson takes a liking, though he is unsure if she is a lesbian. While the group discusses the death of Screw, they remain certain they are safe at school, not noticing the chaos that surrounds them, including a nuclear bomb being built and the killer attempting to murder a student as well as making an attempt on the presidents life.