Four lifelong stoners and friends (Kenny, Thurgood, Scarface, and Brian) live together in New York City. Thurgood, a janitor at a medical laboratory, brings home some unusually potent marijuana given to him by an unscrupulous scientist at the lab and the four smoke it. When Kenny, a gentle kindergarten teacher, is out on a munchie run, he is arrested for accidentally killing a diabetic police horse by feeding it junk food. His friends are forced to find $1,000,000 to bail him out before the other prisoners take advantage of his gentle nature. Scarface gets the idea to have Thurgood steal medical marijuana from his work so that the three of them can sell it to raise money to free Kenny. While visiting Kenny in prison, Thurgood meets Mary Jane and pursues a romantic relationship, which is strained by his having to conceal his marijuana smoking and dealing from her, as she is adamantly anti-drug.