Set in the seedy parts of New York City, ''Killer Condom'' follows gay Detective Luigi Mackeroni (Udo Samel), who has been hired to investigate a series of bizarre attacks at the Hotel Quickie in which male guests have all had their penises mysteriously bitten off. While at the crime scene, he enlists the services of a gigolo named Billy and invites him up to the crime room. Before the two men engage in sex, a carnivorous living condom interrupts them and bites off Mackeroni's right testicle.