After being released from the prison mental ward, Coffin Joe is greeted at the gate by his old and loyal servant Bruno (Rui Rezende), who takes him to a secluded basement below a ''favela'' in São Paulo. As well as Bruno, the hideout is populated by four fanatics who are obsessed with Coffin Joe's history and ideas, and have been waiting and preparing for his arrival in order that they may faithfully serve him. After questioning their motives and testing their loyalty, Coffin Joe immediately orders the followers to begin kidnapping women so he can renew his murderous quest for "the continuation of the blood", his lifelong obsession to find who he determines to be a perfect woman who will bear him a son. His first victim is Dr. Hilda (Cléo De Páris), a controversial Eugenics who Bruno kidnaps. Coffin Joe tests her will by injecting her with drugs and she has hallucinations of Coffin Joe cutting off her buttock and presenting it to her after which she willingly eats it. Meanwhile, Coronel Claudiomiro Pontes (Jece Valadão), a fervently Roman Catholic Church police captain who holds an old grudge against Coffin Joe for blinding his eye, and Father Eugênio (Milhem Cortaz), a mentally unstable priest (the son of one of Coffin Joe's past victims, Dr. Rudolfo in ''At Midnight I'll Take Your Soul'') learn about Coffin Joe's release, and decide to join forces to seek Coffin Joe and kill him once and for all.