In 17th-century England, Irish doctor Peter Blood is summoned to aid Lord Gildoy, a wounded patron who participated in the Monmouth Rebellion. Arrested while performing Hippocratic Oath, he is convicted of treason against James II of England and sentenced to death by the infamous George Jeffreys, 1st Baron Jeffreys. By the whim of the king, who sees an opportunity for profit, Blood and the surviving rebels are transported to the West Indies to be sold into slavery.