John awakens from a coma to find that his wife and daughter were brutally murdered in a home invasion. With the help of Federal Bureau of Investigation Agent Gorman, the still amnesiac John identifies the perpetrator as former Universal Soldier (UniSol) Luc Deveraux, now a wanted man. Gorman activates sleeper agent Magnus, one of the cloned Next Generation UniSols from ''Regeneration''. Magnus reaches a brothel and kills all the women working there and most of the patrons, all men with exceptional physical resistance. His last adversary, a clone of UniSol Andrew Scott and Deveraux's former nemesis, incapacitates Magnus and injects him with a serum that frees him from government control. Magnus is introduced to a separatist group led by Deveraux and Scott, who are taking in wayward UniSols to turn them against the U.S. government, thus establishing a new order ruled by UniSols.