Hasegawa Kodaka is a recent transfer student to St. Chronica's Academy, a Catholic high school. As with every other school he has ever attended, he finds it difficult to make friends there because of his naturally-blond hair (inherited from his deceased English mother) and fierce-looking eyes, which make him look like a dangerous "yankee" to his prejudiced schoolmates. One day, Kodaka accidentally comes across the equally solitary and very abrasive Yozora Mikazuki while she converses with her imaginary friend Tomo. Realizing that neither of them have any social lives, they decide that the best way to improve their situation is to form a club – the Neighbor's Club – precisely intended to make friends and learn social skills.