In 1967 in Dublin, the unexpected death of Agnes Browne's husband sends her family, consisting of seven children aged between two and fourteen, into emotional turmoil and financial crisis. She is forced to borrow money from a ruthless loan shark named Mr. Billy to make ends meet. She faces her dismal existence by selling fruits and vegetables at an open-air market based in Dublin's Moore Street where she spends time with her best friend Marion, who proves to be a great source of encouragement in her difficulties.