Eddie Jilette is a Chicago cop on the vengeance trail as he follows his partner's killers to New Orleans to settle his own personal score. Eddie flees through the Louisiana bayous with Michel Duval, the beautiful Cajun mistress of a murderous crime lord who aims to destroy the Chicago detective before he can avenge his partner's murder. Michel and Eddie fall for each other, although they clash repeatedly while handcuffed together as they attempt to elude the brutal underworld figure and his henchmen.